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Antibodies to TRC105 were not detected in patients treated with TRC105 from Chinese hamster ovary cells being used in ongoing phase Ib and phase II studies.
Brincidofovir was designed to interfere with viral DNA replication, and it's now in ongoing phase III trials against cytomegalovirus and adenovirus infections; about 1000 people have received it.
UCN-01 is currently involved in ongoing Phase II trials for metastatic melanoma.
In numerous animal studies, as well as in ongoing phase 1 clinical trials, DAS181 is well-tolerated ([15] and unpublished data).
Furthermore, WST11-VTP has shown promising results in ongoing Phase II clinical trials for the treatment of localized prostate cancer in patients who have been under active surveillance.
Fostamatinib is currently in ongoing phase II trials for NHL.
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The risk/benefit ratio of treatment with a VEGF pathway inhibitor plus an EGFR inhibitor and chemotherapy has recently been highlighted in an ongoing phase 2 study in NSCLC, in which 48% of patients achieved a partial response and 22% achieved stable disease.
This agent demonstrated a reasonable progression free rate of 31.6% at 12 weeks in leiomyosarcomas and is being actively studied in comparison to dacarbazine in an ongoing Phase III trial (NCT01327885).
26 The efficacy of nilotinib was confirmed in three ongoing phase II studies in imatinib-resistant or intolerant patients with CML in chronic, accelerated, and blastic phases (Table 2).
Lapatinib is currently under investigation in combination with WBRT in an ongoing, phase I trial [ 41].
For example, possible synergistic effects of ipilimumab and intratumoral IL-2 are being evaluated in an ongoing phase II trial in advanced melanoma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com