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Between-group comparison showed that the increase in ongoing activity of cells activated by formalin at each point of recording within the same time interval was significant compared to the saline-treated ones (P < 0.001, Mann–Whitney Wilcoxon test; Fig. 3a).
In turn, subcutaneous injection of formalin produced a pronounced increase in ongoing activity in 11 (55%) of formalin-treated units.
Injection of α,β-meATP into the temporal muscle caused progressive increase in ongoing activity of most of the spinal trigeminal neurons within 30 min.
A group of neurons demonstrating an increase in ongoing activity after subcutaneous formalin (N = 11) showed also significantly enhanced responses to electrical stimulation of the dura mater (P < 0.0001, Fr = 54.0, Friedman test).
Thus, trigeminal neurons demonstrating biphasic increase in ongoing activity after subcutaneous formalin were also characterized by the enhancement of responses to electrical stimulation of the dura mater with similar time profile.
L-LTP was repeatedly induced at all synapses, and periodic prolonged decreases in ongoing activity were imposed at all but one of the synapses.
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Specifically, we are interested in measuring user engagement and how they develop from a peripheral participation to centripetal participation in ongoing activities of the community.
The children were observed to participate in ongoing activities, and the teachers' focuses were on children's interest, experience and knowledge formation in relation to the overall goals for preschool.
This is the first study to demonstrate that subcutaneous injection of formalin into the orofacial receptive field of the STN neurons results not only in biphasic increase in their ongoing activity, but also in an equal enhancement of neuronal responses to electrical stimulation of the dura mater, which has similar time profile.
Subcutaneous formalin resulted not only in the biphasic increase in the ongoing activity, but also in an enhancement of neuronal responses to dural electrical stimulation, which had similar time profile.
A group of trigeminal neurons, unresponsive to subcutaneous formalin, was also revealed and it did not demonstrate any changes in their ongoing activity or in evoked firing.
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