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As a new and alternative solution to the trial for subjects who are treatment-experienced, we propose using different designs for null responders and others (partial responders and responder relapsers) in one single trial.
This risk, however small, needs to be balanced against the knowledge that the broad scientific trial results will only provide information about an average treatment effect of the experimental vs control treatment in one single trial, which should be viewed in the context of the worldwide evidence.
Similar(58)
Any duplicated publications were combined to represent one single trial.
The bone scan response to radium-223 has only been described in one single center trial of 14 patients, none of whom achieved the outstanding bone scan response presented in the current case.
In fact, there is currently no validated method to quantify decreased tumor burden on bone scan, and to our knowledge, the bone scan response to radium-223 has only been described in one single center trial of 14 patients, in which bone scans were obtained at baseline and one month after the 6th dose of radium-223.
The test was performed in one single day and consisted of 50 trials per animal, as previously described (Aguilar et al., 2000).
It was designed as a prospective open-labelled phase II trial, performed in one single institution (University Hospital Bretonneau in Tours, France).
The only three randomized trials conducted evaluated standardized minimal acupuncture in one single point.
The only three published randomized controlled trials were conducted in private clinics and evaluated standardized minimal acupuncture in one single point.
The bone data from two independent long-term randomised clinical trials testing K alkali supplements against placebo in healthy postmenopausal women have been analysed in one single publication.
In one single night.
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CEO of Professional Science Editing for Scientists @ prosciediting.com