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This was done in a careful manner by taking detection of differential expression in one progression state as evidence for the other and included a gene in the extended set if the detected microarray probe set suggested more than 2-fold expression change.
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So, although patients are recruited from two different hospitals, they will be treated as one progression step in the stepped wedge, and move to the intervention period at the same time.
Five patients did not complete consolidation chemotherapy because of progressive disease: ascites (one); progression in pancreas (one), liver (one), both pancreas and liver (one), and site not reported (one).
In our study, we observed progression of scoliosis in one patient, progression of kyphosis in one patient (which did not occur until year 2 of treatment), and improvement of kyphosis in one.
At 3 months after SRT, two patients had died of progressive disease: diffuse-invasive and infiltrative progression in one patient and disseminated progression in the other.
Reported outcomes varied with kidney recovery in one-third, progression to ESKD in the majority and death in four patients.
In 2 patients surgical resection was performed as a salvage procedure for disease progressing on IM (primary progession in one case and progression following initial response in another case).
When Federer reviewed some of the images she had taken, she was startled to see that in one five-image progression, something unusual appeared.
No objective response to treatment was observed; 1 stable disease occurred in one patient and progression in eight.
In one patient, disease progression after intraarterial chemotherapy was associated with deterioration of portal hypertension and, consecutively, fatal gastrointestinal haemorrhage.
In one patient, disease progression was systemic (peritoneal carcinosis) rather than local at the 500 mg m−2 twice daily dose level.
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CEO of Professional Science Editing for Scientists @ prosciediting.com