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The pharmacokinetic parameters of peak concentration (Cmax) and area under the concentration time curve in one dosing interval (AUC0 τ) and AUC0 72 h are determined in such studies.
In one dosing experiment, a single dose of i.v. injection of PEG minocycline-liposomes or PBS (control) was given at disease onset.
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Cassette dosing is also known as N-in-One dosing: several compounds are simultaneously administrated to a single animal and then the samples are rapidly detected by LC MS/MS.
Some products deliver the buzz of at least three cups of coffee in one dose.
Taken in one dose, these three tales sound like plotlines from an overwrought doorstop of a novel.
The vaccine was administered in one dose, to ≥18-day-old piglets via drinking water.
"Street-level heroin is rarely pure and can sometimes be cut with drugs or compounds that can kill you in one dose," he said.
For House of Cards fans there can be only one option for date night this Valentine's Day – an all-night session watching the second series of the hit US political drama as Netflix repeats its trick of making all 13 episodes available across the globe in one dose.
With IORT, the radiation is delivered in one dose during the surgical removal of the lump.
Another 133 people in the studies had a history of anaphylaxis after a vaccine, but none experienced anaphylaxis or an allergic reaction after another vaccine (received in one dose or in three partial doses separated by an hour).
In one dose-finding RCT (n = 417) headache relief was 18% with placebo, and 21, 45, and 48%, with rizatriptan doses of 2.5, 5, and 10 mg, respectively [10].
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