Exact(19)
EQ-5D-3 L patient-level data from a clinical study of lubiprostone in OIC (n = 439) were scored using the UK tariff.
While the mapping by Parker et al. in CIC appears to demonstrate a good fit between the PAC-QOL and the EQ-5D-3 L in CIC [10], we found no such relationship in OIC.
Searching the Oxford Mapping Database, a study by Parker et al. reported a mapping between the PAC-QOL and the EQ-5D-3 L utility in chronic idiopathic constipation (CIC), but no report on mapping in OIC was found [10].
As CIC patients experience the same symptoms (with the same endpoints and scales used in clinical trials), our expectation was that a similar relationship would exist between the PAC-QOL and EQ-5D-3 L in OIC and CIC.
A possible explanation for the failure of the mapping exercise is that although the outcomes are the same (utility and PAC-QOL scores), the trials were conducted in different populations; the study by Parker et al. was in CIC, while Study 1033 was in OIC with chronic non-cancer pain.
65 Lubiprostone has been a potential candidate in OIC treatment.
Similar(40)
In two experiments rats received training on an object-in-context (OIC) task, in which they received preexposure to object A in context x, followed by exposure to object B in context y.
One version of this, the object-in-context (OIC) task, is used to assess rodents' ability to remember where they have encountered a specific object.
In Afghanistan, one in six pregnancies results in death; in African OIC Member States, the average is one death for every 15 pregnancies.
In this study we will evaluate differences in efficacy of methylnaltrexone in reducing OIC between the commonly prescribed opioid subtypes morphine sulphate, oxycodone and fentanyl.
The published mapping in CIC performed poorly in this OIC population, and the PAC-QOL could not be reliably mapped on to the EQ-5D-3 L even when re-estimating coefficients.
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