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Extending the reference period to the end of the MHT time series by definition results in no net change in OHC due to the integrated MHT divergence and atmospheric fluxes but forces a significant trend in OHC throughout the time series (section S2).
Effects of the increase and decrease in the OHC maximum force on cochlear amplification were also analyzed since such changes in OHC force have been reported in previous studies.
However, although there is a corresponding decrease in OHC, this decrease is not significantly different from zero relative to the estimated error for OHC.
To explore how the long-term changes in OHC components are distributed spatially in the 0 700 m layer (and 0 2000 m layer in Figure S2) we compute OHC difference based on 15 year periods, (1961 1975) and (1995 2009), which are common for all three reanalyses.
It has been previously shown that ototoxicity induced by AGs is a result of irreversible damage in OHC [18].
As shown by electric stimulations in DCs (Fig. 1C and D), the uncoupling of gap junctions between DCs caused significant changes in OHC NLC (Fig. 4C E).
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So, the possible local ionic changes in the DC cup area near the OHC basal pole cannot evoke the significant electric changes in OHCs.
The results of this study indicate that F-actin cleavage is an important early cellular event in apoptotic development in OHCs following exposure to traumatic noise.
What is the physiological significance of this seemingly paradoxical role of prestin in OHCs?
Compared to single cells, the MTT reduction in OHCs was less frequently investigated.
After 14 days of drug treatment, some TUNEL reactive cells were observed in OHCs (Fig. 2Bc).
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