Sentence examples for in numerous phase from inspiring English sources

Hence, a combination chemotherapy of 5-FU with oxaliplatin has been investigated in numerous phase II studies, using different doses and schedules [ 3- 7].

To date, DNA vaccines have been tested in numerous Phase 1 and Phase 2 clinical studies, both for prophylactic and therapeutic purposes (reviewed in refs. 14 and 15).

Various chemotherapy regimen have shown limited activity in numerous phase II trials, resulting in response rates from 15 to 50% and a median survival of 4 11 months.

Two fully human IgG monoclonal antibodies recognising CTLA-4, ipilimumab (MDX-010) and tremelimumab (CP-675,206), have been tested, alone or in combination, in numerous phase II trials and in four phase III trials.

MGCD0103 is an orally active benzamide HDACI currently being assessed in numerous phase I-II trials for hematological malignancies and solid tumors in single-agent therapy or in combination with azacitidine, gemcitabine, or docetaxel [ 13].

The efficacy of trabectedin has been shown mainly for lipo- and leiomyosarcomas in numerous phase II and compassionate use programs, although other STS subtypes may also benefit equally from the drug, such as synovial sarcoma.

The dosing of the different agents in the regimens is outlined in the footnote to Table 3. Numerous phase III trials have looked at the differences between FOLFOX and XELOX in first- and second-line settings, some of which have been published only in abstract form.

However, this alone also does not justify further evaluation of oxaliplatin for particular groups such as patients unable to receive a cisplatin-based combination, because for this setting, especially in terms of reduction of non-haematological side effects, carboplatin is a well-established alternative for cisplatin, as shown in numerous randomised phase II and III studies.

H2O2 accumulation has been detected in numerous transitional phases of development: in grapevine at the moment of bud break [ 25], in sunflower during seed dormancy release [ 26], in tomato and grapevine at fruit ripening [ 3, 27] and in Arabidopsis at floral transition [ 28].

Based on an autobiographical novel by Carolyn S. Briggs, the film covers many years and numerous phases in its protagonist's journey, from immersion in religion to resentment over its failings.

After building out prototypes with this vision in mind, the team went through numerous phases of research including in-person interviews with users, large-scale surveys, and even pushing a beta version of the redesign to a small group of users.