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The activator protein-1 (AP-1) complex plays a crucial role in numerous pathways, and its ability to induce tumorigenesis is well documented.
Due to HSP90's central position in numerous pathways regulating growth and development, the chaperone has emerged as a principal focus of investigation in diverse fields.
Combination of samples from all microarray platforms revealed 17 common DE genes, (BMP4, CRYGD, DBH, GJB1, KRT83, MPZ, NHLH1, TACR3, ACTC1, MFAP4, SPARCL1, TAGLN, TPM2, CDC20, LHCGR, TM9SF1 and HCCS) 4 of which participate in numerous pathways.
Early IVD degeneration involved significant changes in numerous pathways, including Wnt/β-catenin signaling.
But if there are many mutations in numerous pathways, the harmful impacts of these mutations cannot be compensated.
The involvement of p130Cas/BCAR1 in numerous pathways driving mammary cell transformation is due, at least in part, to its function as a mediator of integrin-dependent signalling.
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For many drug target systems, genomics approaches, e.g., by RNA array analysis of gene expression, have revealed that receptor stimulation results in numerous pathway regulations.
In sepsis, bacterial infections trigger numerous pathways resulting in activation of key antigen-presenting cells (APCs) (i.e., monocytes/macrophages, dendritic cells).
The remaining clusters were not enriched for GO categories because of the many unannotated genes in the transcriptome, suggesting that numerous pathways involved in stress tolerance are yet to be revealed.
Finally the microenvironment that results from being embedded in a self-produced matrix results in the induction of numerous pathways associated with stress tolerance.
The changes in the levels of miRNA expression have been observed in many human malignancies, and affected numerous pathways involved in apoptosis, proliferation, survival and invasion.
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