Bcl-2 protein was abundantly immunolocalized in syncytiotrophoblasts in normal term placentas, but least abundant in term placentas complicated by severe preeclampsia or intrauterine growth retardation.
The expression of VEGF and VEGFR-2 mRNAs was significantly lower in normal term or diabetes type-I placenta compared to human endometrium (P≤0.01).
The apoptosis positive rate of syncytiotrophoblast nuclei in severe preeclamptic and intrauterine growth retardation term placentas was significantly higher than that in normal term placentas (severe preeclampsia, P <.001; intrauterine growth retardation, P <.01).
To describe cardiac function, cerebral regional oxygen saturation (rSO2), and cerebral blood flow (CBF) that correspond to changes in arterial oxygen saturation (SaO2) in normal term neonates immediately after birth and after the transition.
Study design: We measured mRNA expression of vascular endothelial growth factor (VEGF), angiopoietin 1 and 2 (Ang-1 and Ang-2), their receptors VEGFR-1, VEGFR-2, Tie-2, fibroblast growth factor 2 (FGF-2), and its receptor FGF-2R in placental tissue of diabetes type-I patients, in normal term placenta, and endometrium of non-pregnant women by real time reverse transcriptase PCR.
Maternal anti-HLA class I seropositivity was higher in chronic chorioamnionitis cases than in those without chronic chorioamnionitis both in normal term births (63.2% vs. 27.3%, p = 0.002) and spontaneous preterm births (66.7% vs. 36.1%, p<0.001).
We analyzed maternal and fetal sera for panel-reactive anti-HLA class I and class II antibodies, and determined C4d deposition on umbilical vein endothelium by immunohistochemistry. Maternal anti-HLA class I seropositivity in spontaneous preterm births was higher than in normal term births (48.6% vs. 32.1%, p = 0.005).
Another limitation of the present study is that we did not perform DTI in normal term infants.
This is very important from the point of view of the metabolic pathogenesis of RP in cows which have their parturition in normal term.
sMIC was more frequently detected in the plasma of women with a diagnostic of VPD (32%) than in normal term-matched pregnancies (1.6%, P < 0.0001), with highest prevalence in intrauterine fetal death (IUDF, 44%) and vascular intrauterine growth restriction (IUGR, 39%).
