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To verify whether histone acetylation under hypoxic condition can result in NEP down-regulation, we performed ChIP assay and q-PCR to determine the interaction of H3-Ace and NEP promoters.
High levels of interannual variation in NEP were predicted for most MLRAs of Alaska.
In this study, we developed a model, LandNEP, to follow the change in NEP by ecosystem and chronosequence.
Seasonal changes in simulated CO2 fluxes and resulting inter-annual variability in NEP corresponded to those derived from EC measurements.
Varying humidity and supplies of water led to a range in NEP of 0.8 2.7 kg C m−2 year−1.
An analysis of residuals indicated that for the most part no obvious trends were evident; although a slight bias was detected in NEP with soil temperature.
Similar(18)
Moreover, comparing the results of thiorphan-treatment [11], [34], [35] with experiments in NEP-knockout mice, we have to consider that thiorphan inhibits further NEP-like peptidases whose activities are not impaired in NEP-deficient mice [18].
Our first experiment focused on detecting possible Aβ depositions in NEP-deficient brains of mice at very different ages.
An incidental observation in NEP-deficient mice was a late-onset excessive gain in body weight exclusively from a ubiquitous accumulation of fat tissue.
Thus, we investigated, whether the obese phenotype in NEP-deficient mice could also be generated by a more acute pharmacological inhibition of that peptidase.
Since the development of obesity in NEP-deficient mice starts at 6 7 months, this is an ideal model for typical human late-onset obesity.
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