Because triglyceride module five correlates with all three gross phenotypes, its correlated genes, which include a probable cytochrome P450, Cyp313a4, and a signal transduction gene, CG32082, are particularly exciting and in need of further functional experimentation and validation.
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Beyond providing novel pathobiological insights in need of more sophisticated functional annotation, gene variation might in the future be instrumental in precise risk stratification and the development of genotype-based treatment algorithms.
Basic research and possible clinical applications are in need of a universal, functional titration method for any transgene-of-interest, for example by qPCR.
It is yet to be established which melanomas may be susceptible to treatment with a combination of antiangiogenic agents and chemotherapy, and current treatment monitoring is in need of a reliable functional imaging tool.
Included in the CHA are items that identify those persons who are in need of further assessment (a "Functional Supplement" is then triggered that will complete the HC).
And Amazon is decidedly in need of something to differentiate its functional, but rather unglamorous, software app from the others in this space.
Although the discovery of such novel proteins that are likely to play prominent roles in brachiopod shell formation is exciting, such results are tempered by the fact that an understanding of the mechanisms of biomineralization in many metazoan model systems is in need of high quality in vivo functional assays.
In a ruling dated April 18, Justice Richard F. Braun wrote that the former inmates were "probably most in need of discharge planning due to their serious functional impairments".
Cohen calls such background accounts 'elaborations' and he concedes that functional explanations are in need of elaborations.
