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A sensitive and specific assay for aldosterone is therefore needed to monitor adrenocortical activity in murine studies of renal function and cardiovascular diseases.
To determine the proportion of immunoglobulin recognizing EDIII DENV-2 type-specific epitopes identified as potently neutralizing in murine studies we used two different EDIII mutant antigens.
In murine studies, NKG2D receptor-dependent elimination of tumor cells expressing NKG2D ligands has been well-documented both in vitro and in vivo [1] [6].
In murine studies and other NHP studies, anti-ZEBOV NAb were low or absent yet the animals were resistant to a ZEBOV challenge [35] [37].
We noted that in murine studies, showing the most potent CpG effects, CpG is provided along with the antigen or in close proximity to tumor antigens [12], [18], [19], [20].
DENV-2 specific domain III IgG formed a very small proportion of the antibody response yet was significantly correlated with DENV-2 neutralization, suggesting that the highly protective IgG recognizing this epitope in murine studies plays a role in humans as well.
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Nutlin-3a was also found to exhibit no pathological effect in in vivo murine studies (Vassilev et al, 2004).
In conclusion, we have undertaken a detailed analysis of GCH1 and GFRP using complementary in vitro biophysical analysis with in vitro and in vivo murine studies.
Our subjects were 4 7 weeks of age, prior to the early onset of presbycusis in these mice, which were also used in prior murine studies using GTTR [3], [26], [28], [44].
In vivo murine studies of Gd ⋅1 have shown accumulation of the probe in the pancreas with increased signal intensity over 140 minutes.
In vivo murine studies rapidly spawned the development of new oral small molecule inhibitors designed to inhibit the JAK2V617F-induced constitutively active signaling pathway.
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