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We investigated the ability of testosterone (T) to restore differentiation in multiple population doubled (PD) murine myoblasts, previously shown to have a reduced differentiation in monolayer and bioengineered skeletal muscle cultures vs. their parental controls (CON) (Sharples et al., 2011, 2012 [7,2012.
This panel of samples has been used in multiple population genetic studies [24], [25], [27].
Subsequent comparison of allele frequency distributions in multiple population genomic samples could further test these signatures, and such data could also be used to refine less intensive approaches to identifying selection in pathogens with large genomes.
More statistics models for estimating the genetic effect in multiple population backgrounds are needed.
Interestingly 192 of the rHH genes were significant in multiple population clusters.
Candidate gene approaches in OA research have been debated because suggested associations were rarely replicated in multiple population studies (Reynard and Loughlin, 2013).
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Therefore, in the initial population stage, different individuals in multiple populations are randomly assigned different numerical sizes.
So far, mutational analyses in multiple populations identified loss of function mutants of SHP gene involved in mild obesity, increased birth weight and insulin levels.
A control healthy population was obtained the at the 1000 Genomes Project's website (http://www.1000genomes.org/home): This database provides a broad representation of common human genetic variation detected by next generation sequencing in multiple populations [43].
The increasing number of genetic association studies conducted in multiple populations provides an unprecedented opportunity to study how the genetic architecture of complex phenotypes varies between populations, a problem important for both medical and population genetics.
Trials were conducted from 2005 through 2012 in multiple populations.
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