There was also an absence of gateway enzymes involved in multiple pathways such as ornithine aminotransferase27.
The GO analysis indicated that these DEGs were enriched in multiple pathways associated with disease resistance.
The identified genes were enriched in multiple pathways (p53, DNA repair, WNT, mitochondrial depolarisation), and in particular mitochondrial and p53 dysfunction may be important drivers of disease.
While abnormalities in multiple pathways may lead to schizophrenia, an abnormality in dopamine neurotransmission is considered to be the final common abnormality.
"They get it in multiple pathways," said Larry Gordy, the rancher who found the mine on his property and alerted federal officials two years ago.
Proteins involved in multiple pathways, including jasmonic acid synthesis proteins and oxidative stress-response, showed significant changes in expression pattern in response to BPH feeding.
Together, the findings from this study indicate that clusters of metabolites involved in multiple pathways not directly connected with cholesterol metabolism may play a role in modulating the response to simvastatin treatment.
Hence, DDX3 is involved in multiple pathways of RNA sensing and signaling during viral infection.
Ataxin-1 is involved in multiple pathways as suggested previously and each of these might contribute to SCA1 pathogenesis [26].
In [47], the authors showed that the targets of a specific microRNA cluster are significantly enriched in multiple pathways.
EhCaBP1 is also thought to be involved in multiple pathways as it binds a variety of target proteins observed by immunoprecipitation and mass-spectrometric studies [5, unpublished observation].
