Sentence examples for in multiple mutations from inspiring English sources

Current worldwide initiatives are expected to result in multiple mutations in every mouse gene in the first 10 years of the 21st century.

Based upon these deficiencies and other factors, it is concluded that the umuC strain is near-normal for A T->G C trA T->G Cs, single-base deletransitionsossibly A:T->C:G transversions; is generally deletions for mutandnesis at G:C sites and for transversions, and is grossly deficient in multipossiblytions (A T->C G

The fact that S768I showed high frequencies in multiple mutations suggests a rationale for specific studies designed to explore the role of S768I in NSCLC oncogenesis.

Interestingly, we found high frequencies of S768I in multiple mutation cases: in two triple-mutation cases (2 out of 7) and in 15 double-mutation cases (15 out of 153), in four cases of L858R/S768I and in 11 cases of G719X/S768I.

elegans wild-type) [ 21], and our analysis of transition bias (transition/transversion – Ts/Tv – base substitution ratios) revealed the Ts/Tv ratio = 0.54, which is within the range observed for spontaneous mutations in multiple mutation accumulation lines (average 0.45; range 0.19 – 0.79) [ 21].

This is particularly important in cases in which multiple mutations are present and a cooperative effect needs to be evaluated.

In humans, multiple mutations in the Foxp3 gene can lead to IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked), a syndrome that is similar to Scurfy, with multi-organ lymphocytic infiltration, lympadenopathy, exfoliative dermatitis, hepatosplenomegaly and autoantibodies [4] [6].

Moreover, there has been some progress in identifying multiple mutations in single individuals (Schaaf et al. 2011), suggesting possible multigenic threshold models for ASD (Cook and Scherer 2008).

However, the inherent propensity of different mutants to produce aggregated protein varies, even in cases in which multiple mutations target a single amino acid position.

Further, it is worth emphasizing that these experiments reveal general tendencies in the manner in which multiple mutations interact that can be extremely weak.

Considerable data indicate that cancer progression from premalignancy to malignancy is slow, which is consistent with a natural selection model in which multiple mutations are required in order to reach full metastatic potential.