Thus, WNK-SPAK/OSR1 pathway may be able to be involved in multiple function, and possibly, its activities are modulated through the phosphorylation of SPAK/OSR1 by WNK.
VAPs have been implicated in multiple function including non-vesicular transfer of lipids and membrane trafficking, ER-organelle and ER-cytoskeleton interaction and homeostatic and signaling functions at the neuromuscular synapse [ 10, 14- 16].
This is biologically sensible, as many genes and proteins are known to participate in multiple functions, and hence functional modules can overlap with each other.
An additional 256 (10 %) cytoplasmic proteins were potentially involved in multiple functions and were assigned to more than one functional category (Fig. 3e; Additional file 3: Table S3).
Problems in product and technological development are more easily identified and solved by employing cross-functional teams and by a career development strategy that provides engineers and managers with job experience in multiple functions, including working on the factory floor.
The hippocampus participates in multiple functions, including spatial navigation, adaptive timing and declarative (notably, episodic) memory.
The present experimental design and analysis may be useful to reveal particular brain regions that participate in multiple functions.
GRP78 participates in multiple functions in the cell during normal and pathological conditions, controlling calcium homeostasis, protein folding and Unfolded Protein Response.
In the molecular function (MF) category, based on the counts of enriched genes, Table 1 shows the top 20 terms involved in multiple functions such as nucleoside binding, ATP binding, RNA binding, calcium ion binding, and enzyme binding.
Notably, p53 is involved in multiple functions including growth arrest, DNA repair, senescence as well as apoptosis [29].
By using individual binary GLMs to model each biological function, each gene can be classified as being involved in multiple functions.
