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Intralocus sexual conflict and genetic correlations have been demonstrated in multiple fitness traits in P. interpunctella [ 17].
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If a large percentage of mutations are generally deleterious, then lines accumulating such mutations should show reductions in fitness across multiple fitness components, i.e., positive pleiotropy.
A fitness penalty for each dosage imbalance is assigned and multiple fitness penalties in an individual are assessed multiplicatively.
Previous work found that III M males outperformed Y M males in multiple laboratory fitness assays (Hamm et al. 2009), providing additional support for the accumulation of male-beneficial alleles on the III M chromosome.
Simple implementation to cope with the multiple fitness functions is a weighted summation.
Since there are two fitness components encoded in the polymerases of our model organisms, namely proliferation rate and mutation rate, what we may be observing is the existence of multiple fitness equilibria between the forward and reverse polymerizing organisms.
Bicycling can help with multiple fitness goals.
In contrast to lamB, growth phase-specific buffering patterns in rplS syn did not echo observations in the 40k strain, consistent with the presence of multiple fitness-relevant mutations in the latter.
In contrast, fitness effects of the rplS mutation introduced in isolation into the ancestor of the 40k strain does not track overall fitness patterns for this strain, again consistent with the presence of multiple fitness-relevant mutations in this strain.
Here specialised phage remove ruggedness in the local fitness landscape and allow coexistence of multiple fitness-neutral host strains.
Parallel analysis of pooled cultures also enables rapid analysis of cellular fitness in multiple environmental conditions.
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