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In every iteration, only one stochastic transition is generated, resulting in multiple alternative sequences of molecular interactions.
Noisy nature of high-throughput experiments, however, can result in multiple alternative network topologies that explain this data equally well.
In eukaryotic cells, GO annotations of related proteins to target genes revealed several processes through their domains that carry out diverse molecular functions and participate in multiple alternative interactions with other proteins, organelles, or locations in the cell (Table 4).
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Taken together, fusion-typing of a novel panel of TMPRSS2 ETS fusion markers allows detection of diverse fusion types in urine; multiple alternative fusion markers other than the common subtype I provide improved detection of prostate cancer in prebiopsy patients.
Table 6 summarizes the IMMAD occurrence as part of larger sequences and the prominent co-occurring IMMAD partners.> The present study confirmed the hypothesis that specific sequence elements occur more frequently in introns flanking alternate exons in genes where multiple alternative splicing decisions occur, as compared to genes where only one such decision occurs.
The number of possible isoforms can be much higher in genes with Multiple Alternative Splicing decision Sites (MASS), due to the combinatorial arrangement of multiple alternate exons (see an example of MASS gene in Figure 1B).
This is actually an approach to restoration ecology that is based in the existence of multiple alternative states in complex ecosystems [ 60, 66].
The alternative part can consist of several segments in case of multiple alternative PAS.
In genes with multiple alternative transcription start and/or pre-mRNA processing sites, their combinatorial potential exponentially increases the number of possible products, with some human genes predicted to express >100 mRNA isoforms.
Most of the remaining motifs are not part of repeated sequence elements, but tend to occur in specific heterologous pairs in genes subject to multiple alternative splicing decisions.
Analysis of expressed sequence tags (ESTs) indicates that transcripts produced from this gene (Fig. 1A) are alternatively spliced, utilizing multiple alternative exons and, in exon 5, alternative splice donor sites (Fig. 1B).
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