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Induction of podoplanin expression results in multiple adjustments of intracellular signalling pathways, leading to the modulation of Rho family GTPase activities, the phosphorylation of ERM proteins, rearrangement of the actin cytoskeleton and, finally, enhanced cell migration and invasion.
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In contrast to multiple adjustments of the individual BR in a child starting CSII based on only anecdotal assumptions like a biphasic dawn-dusk (BC) pattern or any other arbitrary age-adjusted pattern, commencement of CSII in children will profit from a standardized and differentiated approach assigning an optimal pattern a priori.
A multivariate survival analysis was then conducted but failed to demonstrate any difference in survival despite multiple adjustments.
The epidemiological approach provides the advantage of the possibility of collecting large samples with a long duration of follow-up; however, in observational studies multiple adjustments for confounders can never fully eliminate the prescription bias (i.e., the effect of differences in characteristics of patients on different therapeutic choices).
In particular, the effect of opioid exposure was robust, and remained after multiple adjustments in cross-sectional and longitudinal studies.
The overall mortality risk was attenuated after multiple adjustments in Cox models 1 3, but remained statistically significant in all the multivariable analyses.
Survey weights were applied to each model to account for multiple adjustments in the sampling procedure to ensure that the sample was representative of all US adults.
These are attenuated after the multiple adjustments in Model 1 but there is still evidence to suggest that on average, better overall raw scores or "crowded scene" scores are associated with better reading test results.
We addressed these weaknesses with multiple adjustments in our multivariate analyses.
Sixth, associations could be the chance findings because we did multiple adjustments in the statistical analyses.
This might have been due to multiple adjustments in the multivariable model, which reduced the impact of heart failure.
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