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Here, we evaluated whether targeted delivery of MSCs with triple PSGL1/SLeX/IL-10 engimproves improves therapeutic outcomes in mouse experimental autoimmune encephalomyelitis (EAE), a murine model for human MS. We found PSGL-1/SLeX mRNA transfection significantly enhanced MSC homing to the inflamed spinal cord.
Therefore, a possible benefic effect of Treg attenuation during BCG immunization on M. tuberculosis induced host mortality cannot be evaluated in mouse experimental model.
We confirm that claudin-15 is a direct Hnf4α gene target in the intestinal epithelial context and is down-modulated in mouse experimental colitis and inflammatory bowel disease.
Several recent reports have shown the antifibrotic effects of Sirt1 in mouse experimental models [ 44, 46].
In our study, we have evaluated the expression of UbcH10 in human thyroid neoplasias and in mouse experimental tumours.
In mouse experimental sepsis, the serum AGP concentration was significantly increased only 6 hours after severe sepsis.
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In mice, experimental inflammation during embryonic development impairs behavioral and cognitive performances in adulthood.
In mice, experimental reduction or mutations of miRNAs in the inner ear leads to severe developmental and structural abnormalities.
In this work, in a mouse experimental model, we report the age-related reduction of spleen hematopoietic tissue (SHT) complexity.
In contrast, IFNγ has a protective effect in the mouse experimental autoimmune encephalomyelitis model [4].
Despite some clear successes, translation of immunological discoveries in the mouse experimental autoimmune encephalomyelitis (EAE) model into effective therapies for MS patients has been difficult.
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