This compound also inhibited tumor growth of the LNCaP xenograft in mice dose-dependently.
After 24 hpi, we could not detect the ricin in feces in mice dosed with 200 µg/mouse or less.
While extremely low doses of HPV-VLP appear immunogenic intramuscularly in mice, doses for humans in the approved vaccines are in the 20 40 µg range per subtype.
In mice doses of 1 µg elicited geometric mean neutralizing titers of 1∶297 and in rabbits doses of 5 µg elicited titers of 1∶453.
Another study investigated the effects of BE on the central nervous system (CNS) with the conclusion that there was no effect of BE on muscle tone and coordination in mice; doses up to 100 mg/kg bodyweight were used [38].
In mice dosed with lolitrem B, heart rate was decreased by 42% 2 h after treatment which persisted for a further 8 h, followed by a slow recovery over 4 days (Fig 1C).
Growth of PC-3 xenografts was also significantly reduced in mice dosed with 0.5 mg/kg silvestrol for 8 consecutive injections following appearance of the tumors 24 days after implantation (Fig. S8).
The MMC also significantly inhibited methamphetamine-induced stereotypy behaviour and climbing time in mice dose-dependently.
In mice, doses of 1250 mg/kg/day led to maternal toxicity, including fetotoxic effects.
Pharmacokinetic analysis was performed in mice, dosed at six different times (24-h period).
