This process was informed by the GTI's experience in high throughput microarray experimentation and took in consideration published literature[ 11, 12, 14- 18].
The second version of the exercise, termed the "active math" version, was identical in content to the passive math version except that the accompanying questions included a series of hands-on computational tasks in addition to questions related to the interpretation of biostatistics in the context of microarray experimentation.
In the early days of microarray experimentation, an emphasis was placed on analyzing the data using exploratory data mining techniques, such as hierarchical clustering [ 10] and self-organizing maps [ 11].
When the certain group of genes was isolated for further processing from microarray experimentation, tumor types were successfully classified based only on these specific genes.
Although other factors need to be investigated to validate the use of cross-species microarray experimentation, our results indicate reproducibility of the data should not be a limitation in cross-species microarray experiments.
A final consideration for microarray experimentation is the potential for multiple sources of variation.
The authors would like to thank the TJU Cancer Genomics Facility staff (Kimmel Cancer Center, Thomas Jefferson University) for their contributions related to the microarray experimentation.
Gene expression profiling, including quantitative RT-PCR (qPCR) and microarray experimentation, is invaluable for the molecular analysis of biological systems.
Herein, we review the most recent advancements in microarray technologies, with a special focus on peptide microarray, small molecule microarray, and protein microarray.
To accommodate both users who are in the middle of their experimentation and data analysis process and those who have already published their results, the platform provides two important mechanisms, both of which are based on the Minimum Information About a Microarray Experiment (MIAME) standard [ 47].
