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On the basis of our findings, we see a need for the improvement in methodology when dealing with clustering in RCTs.
There is a large variability in methodology when measuring component alignment following TKA, and further studies are required to investigate optimal component placement, not only with respect to implant survival but also to patient-reported outcomes following primary TKA.
The lack of consistency in methodology when generating and reporting international estimates of childhood-cancer survival could lend support for a similar collaborative comparative study equivalent to the CONCORD study for adults (Coleman et al, 2008).
Care, however, has to be taken when comparing questionnaire and clinically based studies for a number of reasons, for example, the highly subjective nature of dental pain and the variation in methodology when assessing DHS in different populations [ 16, 26, 27].
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Ueda seems less precise in his methodology when it comes to the look of his games.
Obviously, it is necessary to consider potential biases caused by differences in perspectives and methodology when making such comparisons.
There was little difference in the accuracy of the methodology when directly compared here, and although the hot spot method had a slightly lower area under the curve value, and was subjective, it was quicker.
The most important lesson in methodology from our study is that the combination of genomics, physiology, systems biology, and computational analysis is capable of overcoming the shortcomings of each individual methodology when used in isolation and is able to produce viable results.
Our lack of understanding of this matter may be due to improper methodology when modeling age in statistical analysis.
The ADAS-CogIRT methodology required significantly fewer patients and shorter trial durations as compared to the current scoring methodology when both were evaluated in simulated clinical trials.
In silico methodologies, when integrated with in vivo engineering methods, lay the groundwork for understanding multicellular organisms and their genomes.
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