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These changes in protein expression may be involved in mediating the effect of hypergravity on the developing rat cerebellum.
The NTG-evoked c-fos expression in the TNC was also attenuated after subacute BBG treatment, which implicates a role for the TNC in mediating the effect of BBG on NTG-induced thermal hypersensitivity.
Together, these results suggested ERK signaling pathway was involved in mediating the effect of TNF-α on OECs migration.
We then analyzed the role played by MAPKs in mediating the effect of doxorubicin on senescence and p16INK4A induction.
The knockout of SREBP1c abrogated the ability of ritonavir to induce CD36 (Figure 7H versus 7G) highlighting a putative role of SREBP1c in mediating the effect of ritonavir on CD36.
In order to examine the involvement of CB1 in mediating the effect of ghrelin, the CB1 antagonist AM251 (1 µM) was added to the extracellular solution and 15 min later ghrelin was administered (100 nM).
To better understand the role of the MCS in mediating the effect of diet composition and quality onto energy balance, we have dissected out the implication of several cellular and molecular components of the MC system in the control of food intake by nutrients.
This finding supports a system-based model of perceived emotionality in which the amygdala has a central role in mediating the effect of context-based processing style by recruiting neural operations involved in both visceral (i.e. 'low') and cognitive (i.e. 'high') related processes of emotions.
We further identified RARβ as the key nuclear receptor in mediating the effect of fenretinide.
Further studies are needed to identify genes involved in mediating the effect of miR-146a on FAF1 expression.
In addition, these data confirmed a clear involvement of PPAR- α receptor in mediating the effect of PEA.
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