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And programmes to hand out vitamin A supplements in massive doses to reduce child mortality have brought little discernible improvement.
Lee is currently researching spectinomycin, an antibiotic introduced in the 1960s to treat gonorrhoea, before being cast aside as it only worked in massive doses.
Some believe that, administered quickly and in massive doses, the steroid can reduce inflammation and suppress the toxic cascade of neurochemicals released in the spinal cord after a catastrophic injury.
In 1999, Nakagawa was involved in treating two employees of JCO, a nuclear fuel cycle company, whose mishandling of uranium resulted in massive doses of radiation.
Rookies basically spend 90percentt of their time on the job taking in massive doses of heavy, heavy shit.
According to a 1999 World Health Organization evaluation of studies on the effects of azodicarbonamide, there was a negligible impact from the chemical in animal test subjects, except in massive doses.
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Keeping in mind the stark differences between the economies of the US and Japan one of the lessons that Treasury Secretary Tim Geithner, then a young financial attaché in Japan, "took away from that experience is that spending must come in quick, massive doses, and be continued until recovery takes firm root".
And, for the most part, it preferred to see solvency, so it treated the patient for illiquidity, prescribing, in effect, massive doses of its paper dollars.
In essence these massive doses act in a pseudo-systemic manner.
Victorian England had a tradition of intense but chaste male-on-male friendships, of course, but "we are perfectly entitled," Mr. Jeal asserted, "to question today whether the attempt to deny the undoubted link between love and sexual desire could have succeeded as well as it did without repression, sublimation, and in many instances massive doses of self-deception".
From the biographies it appears that several victims received rather massive doses in a relatively short time (in a single event or in weeks to months).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com