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It has also been compared against other combinations in many phase III trials.
Although improvements in overall survival (the gold standard outcome measure in oncology studies) have been seen in patient subpopulations in many phase III studies of bisphosphonates in breast cancer, only three major trials have been powered to assess overall survival as a primary efficacy endpoint.
The sample size 200 and 2000 were chosen to reflect that the number of patients in many Phase III and IV trials are in the vicinity of 200 and some large meta-analysis may combine several studies and reach around 2000 patients.
The evidence from this process suggests that there are significant inaccuracies in the behavioural and adherence data collected using structured CRF interviews in a clinic setting – the main source of such data in many Phase III HIV prevention trials.
Except for CPT-11, all four chemotherapeutic agents have been examined in many phase III trials in patients with advanced NSCLC and their roles have been mostly elucidated.
In many phase I studies, women of childbearing potential are excluded because there is a lack of fetal toxicity data in animals presenting unknown risks to an embryo or to a woman's reproductive system.
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Germanium is the base element in many phase-change materials, i.e. systems that can undergo reversible transformations between their crystalline and amorphous phases.
In many phases of engineering, the solution of stress and strain distributions in elastic continua is required.
First, Arzner as product of the studio system received consummate professional training in many phases of film production, from editing and scenario writing to directing.
Beyond such bits and pieces, there is the art, whose glory was maintained and renewed in many phases until the artist's death, in 1954: preternatural color, yielding line, boldness and subtlety, incessant surprise.
Not only can such language be used for stating requirements specification, but also can be used in many phases of software development life cycle.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com