Sentence examples for in major difficulties from inspiring English sources

In cases of infection, bacteria adopt a biofilm mode of growth on the surface of the prosthesis, thus increasing the antibiotic resistance and resulting in major difficulties in treatment (Trampuz and Widmer 2006).

There are a lot of younger couples who have taken out mortgages, car loans and so on who will be in major difficulty when the plant finally closes.

Moreover, the great heterogeneity in populations creates major difficulties in distinguishing the side effects of different classes of antiretroviral drugs from one another and from disease complications.

The rural areas in Finland have experienced major difficulties in recruiting physicians in their health centres.

Thirdly, due to the highly repetitive sequences in TALENs there are major difficulties in delivering these by IDLVs due to an inherent propensity of lentiviral vectors to undergo recombination during reverse transcription (Mikkelsen and Pedersen, 2000; Holkers et al., 2013).

At present, the power industry in Nigeria is beset by major difficulties in the core areas of operation: generation, transmission, distribution, and marketing [11].

For example, in Guinea, one of the major difficulties in implementing public awareness measures to prevent hunting and eating of bushmeat is the need to replace bushmeat with some other food!

Radiation induced mechanical property changes can cause major difficulties in designing systems operating in a radiation environment.

In the short term, the introduction of live sound recording caused major difficulties in production.

These noise levels can cause major difficulties in speech communication, and permanent hearing loss in frequently exposed personnel.

In contrast, dogs experienced major difficulties to follow an object's invisible trajectory in these transposition tasks.