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The phrase "in major danger" is correct and usable in written English.
It can be used to describe a situation or individual that is facing a significant threat or risk.
Example: "The hikers were lost in the mountains and found themselves in major danger as the storm approached."
Alternatives: "in grave danger" or "in serious peril."
Exact(1)
PAGE B3 SPORTS ONE TOP PLAYER FALLS; ANOTHER MAKES ESCAPE At the French Open, the women's No. 1 seed, Victoria Azarenka, and the men's No. 1, Novak Djokovic, both found themselves in major danger.
Similar(58)
That's a major danger in humanitarian and political terms".
He showed, it continues, "serious nonfeasance of his duties as prime minister in the face of major danger looming over Icelandic financial institutions and the state treasury".
There is one major danger in implementing Vickers quickly: that having taken this bold step we will be lulled into thinking the regulatory job is over.
Foot complications in this already impaired population constitute a major danger to the overall well-being of the patient and to the fiscal capacity of a health system.
A major danger for unions would be cameras in and around factories, and there are also major privacy issues here for brands.
But that is not the major danger.
But it does carry a major danger.
Phishing is a major danger to web users.
However, there are major dangers in using the 3-D plot in assessing retinal damage.
"One of the major dangers in democracies is this tendency to adopt a moral stance and give lessens in the name of human rights," he said, "to use what Vaclav Havel called, in his unfortunate phrase, humanitarian bombs on distant countries that do not comply with our ideal.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com