The investigation into inbreeding in the competitive world of pedigree dogs resulted in major changes across the industry.
Mergers are taking place among the hundreds of companies that initially provided Part D insurance, and these can result in major changes in coverage.
Many labor experts say they expect a compromise that would be less radical than the mayor's plan but that could still usher in major changes.
Smoking cannabis just once or twice a week could result in "major" changes to areas of the brain important for emotion and motivation, US scientists have said.
But should the grim nature of his crimes and the distasteful way in which he conducted his defence, thus causing further hurt to the Dowler family, be exploited to usher in major changes in the law?
The reorganisation, which has already resulted in major changes within senior management, will involve changes in the way staff work at all levels of the company over the coming years.
"We think there is a critical mass building against the M.P.A.A. on the Web that will hopefully result in major changes to its ratings practices," said Susan Linn, the advocacy group's director.
I don't apologise for attempting to do what previous governments have shied away from, bringing in major changes to make the welfare state fair to both the people who use it and the taxpayers who pay for it.
The findings seem likely to result in major changes, aviation regulators say, that will reduce the amount of time that fuel tanks have an atmosphere that will support fire or explosion.
Forty years on, the two women are still on opposite sides, but this time in an election campaign that looks set to usher in major changes – of the constitution, abortion law, tax and education – in one of South America's most dynamic economies.
The comments, reported in the Courier Mail on Sunday, signal the next priority for the conservative MP will be to force a backdown on the backpacker tax, after he led a successful revolt on superannuation that resulted in major changes to government policy.
