Sentence examples for in loss of interaction from inspiring English sources

Concordantly, mutation of multiple residues in the tail domain preventing Aurora B phosphorylation in vivo produced robust kinetochore MT attachments, whereas mutation in these residues mimicking constitutive phosphorylation resulted in loss of interaction [24], [57].

Knockdown of AKAP79 resulted in loss of interaction between Orai1 and calcineurin after store depletion.

To prove that deletion of KH domain 3 by Caspase-3 results in loss of interaction with the target mRNA sequence, in vitro RNA binding assays were performed.

To date a functional effect has been demonstrated for one of these putative mutations, where V239I (identified in caudal regression syndrome) results in loss of interaction between VANGL1 and DVL proteins (96,).

Replacement of wild-type Cap-H2 by MBM mutant Cap-H2 might result in loss of interaction with Mrg15 and subsequent reduction of complex localization on chromatin, supporting the possibility of Mrg15-independent condensin II function.

Histidine-1047 is located close to the activation loop and the change from histidine to leucine results in loss of interactions with the activation loop making it more flexible.

As in MEFs, the MUS81 loss-of-interaction mutants failed to interact with SLX4 in co-immunoprecipitation experiments (Fig. 2C).

The C19 demethylation and many of 19-hydroxyl and 19-keto substitutions resulted in loss of the interaction with the heme iron and decrease in log P C up to 0.325, which account for 0.724 and 0.640 orders of magnitude decrease in pIC50, respectively.

Indeed, the addition of TnI as an index of 'infarct size' to our adjusted model resulted in loss of the interaction between CVD and DM in predicting mortality, even after accounting for other demographic, comorbid and treatment factors.

Further adjustment for comorbidity and treatment factors outlined in Table 1 (Chronic renal impairment, heart failure, reperfusion therapy, early revascularisation; use of aspirin, clopidogrel, statins, ACE inhibitors and beta-adrenoreceptor antagonists) did not result in loss of this interaction (p<0.006).

Note, that mutations in the phenylalanine of both PAM2-like sequences in Upa1 resulted in loss of Rrm4 interaction.