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In localized forms of the disease, treatment may involve surgical removal of amyloidic masses.
This is through activation of select targets including ataxia-telangiectasia mutated and AMPK, by elevation in localized forms of ROS35,36.
In summary, while the upregulation of miR-21 and miR-141 has been established in metastatic prostate cancer, their modulation in localized forms is still controversial.
PDT has been shown to be useful as a skin-limited treatment in localized forms of MF that do not respond to regular treatments (Table 3).
Of the various forms of periodontitis, aggressive periodontitis is characterized by an early age of onset, with molar and incisor teeth the first ones affected in localized forms [ 5- 7].
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In recent years, the process of localization has undergone changes, mainly due to difficult experiences with various titles, and Square Enix has sometimes developed the titles in localized form first in order to appeal to the western market.
It would be interesting to see whether this predictive property of biomarkers of inflammation and coagulation would also be present in more localized forms of infection and inflammation.
Pneumorrhachis is relatively rare, and usually occurs in a localized form, either in the cervical spine secondary to skull base fractures or in the thoracic spine secondary to pneumomediastinum or pneumothorax.
In the localized form, the signs are lameness and swelling of legs or wing joints.
Invasive disseminated Rhizopus-infections develop in fewer than ¼ of localized forms and have an estimated mortality rate of 78 100% in allo-HSCT recipients [ 8].
The median duration of symptoms before diagnosis was 53 days (15-180 days) overall, and respectively 56 and 60 days in patients with metastatic and localized forms.
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