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Main circuit includes pre-regulator which works in switching mode and series regulator which works in linear mode.
To show the minimum capabilities of the instrument and further applications of it, MBTOF was operated in linear mode.
However, even in linear mode of operation, the mass resolution meets or exceeds that of a quadrupole mass spectrometer with limited power supplies required for operations.
The fast response and the short recovery time of avalanche photodiodes (APDs) in linear mode make those devices ideal for direct X-ray detection in applications requiring high time resolution or counting rate.
The instrument is designed for a multibounce passage of the ion optics and the focal point of the ion optics is optimized for this application, therefore the resolution in linear mode is limited.
The test was performed in a Voyager STR, from Applied Biosystems in linear mode and with an external calibration using bovine serum albumin (BSA).
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The difference in the two times (one is the saturation time in linear-mode fluctuations and the other is the peak time in broadening) is of the order of 50 gyroperiods.
Two different semi-analytical solutions are established, by using the in-vacuum linear mode shapes of the beam and Hermitian finite element basis functions.
Since the masses of glycopeptides can only be obtained in average values in the linear mode of MALDI-TOF/TOF, the monoisotopic values of deglycosylated peptides obtained in the reflectron mode must be turned into average values before the calculation.
However, because the masses of glycopeptides were obtained in average value in the linear mode of MALDI-TOF, the monoisotopic value of peptides and desialylated glycans must be turned into average values before calculation.
The resolution of the spectrometer in the linear mode (red trace in Fig. 1C) did not allow us to determine if the second peak differs from 189 255 by 16 (oxidation) or 14 units (one methyl group).
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