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In line with the speculation that the B-cell arm of the immune response is affected by statin administration is the increased incidence of lupus-like syndromes in patients receiving statins [ 10].
Indeed, we note that the positively charged residues are over-represented among the corresponding motif list (Supplementary Table S5), in line with the speculation that conserved positively charged residues are indicators of some microtubule binding regions (46 48).
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In line with this speculation, the corn smut fungus was shown to cause stronger disease symptoms in maize plants with mutations that prevent them from producing lignin.
In line with this speculation, the increased ratio caused by 5-ARI in men with BPH could be the mechanism behind the unaltered risk of male breast cancer in men with BPH on 5-ARI.
The results were in line with the previous speculation that accumulation of unprocessed precursor proteins in the cytoplasmic membrane was detrimental, and supported the idea that cell death was caused by some unusual tie-up of Pre-Exg with the SecYEG translocation machinery, thus imposing an inhibitory effect on the secretion of endogenous secretory proteins.
In line with this speculation is the observation that patients after successful kidney transplantation have apparently normal EPC numbers and function [12], [21].
In line with this speculation, previous studies have shown that not only the odor quality, but also the odor intensity (odorant concentrations) can influence olfactory preferences [11], [28] [31].
In line with this speculation, several recent reports have shown physical interactions between PKG2 and GSK3 β.
In line with this speculation, TGF β3 but not TGF β1, has been found to be positively associated with lymph node metastasis in breast cancer patients and inversely correlated with the survival of patients with osteosarcoma (Kloen et al, 1997; Li et al, 1998), suggesting that modulating role of TGF β3 in tumour progression may differ in various tumour types.
In line with this speculation, an additive suppression of cell growth with combined administration of EGFR and AKT1 inhibitors compared to individual treatments has been observed in breast cancer MCF-7 cells that are forced to overexpress both EGFR and AKT1 (our unpublished data).
Their profound sequence conservation across divergent vertebrates implies functional implications and, in line with these speculations, in vivo testing of CNEs in transgenic mice assays has confirmed an enhancer potential for the majority of these elements (Pennacchio et al. 2006; Visel et al. 2007, 2009; Noonan and McCallion 2010).
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