In line with the shift towards systems thinking in transport safety, the aim of this study was to compare the normal performance of pedestrians as they navigate the road system with that imagined by road system managers to gain insights into how safety management can be improved for this vulnerable road user group.
To examine whether the first admission to hospital after the age of 60 has been postponed to higher ages for men and women in Sweden, in line with the shift in mortality.
A Markov model estimated the cost effectiveness of ivabradine compared with standard care for two cohorts of patients with HF (heart rate ≥75 bpm in line with the EU labelled indication; and heart rate ≥70 bpm in line with the SHIfT study population).
We also lowered our sales expectations to be more in line with the economic shift and we even adjusted our product offering, marketing language and retail price points to be more in tune with what we felt was the new consumer paradigm.
In line with the paradigm shift currently taking place in psychiatry, the authors have experienced obstacles and success in developing community based mental health care in Southeast Asia.
This would bring AUD research in line with the overall shift in mental health research to understand mental disorders and their treatments using a multilevel framework that includes neuroscience approaches (National Institute of Mental Health 2013).
This approach to model development is in line with the current shift from focus on manipulating individual genes and pathways to the consideration that biological function resides within highly interconnected modules of molecular networks (5, 6).
16 Specifically in the context of cancer, the possibilities this may open for combinatorial therapeutics are very much in line with the recent shift in anticancer drug development from cytotoxic drugs to more specific agents that modulate proteins associated with cancerous states.
In our opinion, the identification of IR-metabolic disruptors is more achievable in the near future using the pathway-based approach, in line with the ongoing shift in toxicity testing strategies from traditional adverse effect based screening toward mechanism-based testing (NRC 2007b).
While the signal appeared predominantly diffuse in the Aβ40+Aβ40 expressing line, we observed a marked accumulation of Aβ40 species in the eye of the Aβ40+Aβ43 transgenic line (**** p < 0.0001, Aβ40+Aβ40 vs. Aβ40+Aβ43, Student's t test, Fig. 9), which is in line with the biochemical shift of Aβ40 species towards the insoluble protein fraction that we observed in the latter combination (Fig. 8).
In line with this shift, perceived scientific orientation, the number of professional journals read and attendance of specialist meetings and events also seemed to favour early adoption, with the exception of high-quality or low frequency PTAMs, which seemed to hinder it.
