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Although both nutlin and RITA induced MDM2 mRNA (Supplementary Figure S14), the protein level of MDM2 was increased by nutlin, but not by RITA, in line with previously published study.
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This is in line with previously published studies, describing as one common source of disagreement between manual entity annotations that some mentions were missed by the curators while scanning over the document [33].
This in line with previously published studies illustrating the importance of PKA in regulation of pancreatic beta-cell function and spermatogenesis [19], [20], [21].
In line with previously published studies (e.g. 2), Tr values were assumed to be equal to values for Ta, and velocity (v) was set at walking speed, 1.2 m/s.
Our observation is in line with previously published studies that were conducted in other European study cohorts: one Greek, one Polish, and one Italian [ 15, 16, 22].
Our results are in line with previously published studies that show season being associated with risk of infection in dairy cattle [ 19, 25].
The mean patient age (54 years) and gender distribution (71 % female) are in line with previously published studies dealing with patients on long-term steroid treatment [ 18].
Supplementation with vitamin C and E is a conservative choice, but the dosages chosen, 1000 mg vitamin C and 235 mg vitamin E (DL-alpha-tocopherol acetate), are in line with previously published studies [ 24, 25, 49- 53, 54] 54].
In the colorectal tumor-associated stromal microenvironment, uPAR expression was furthermore observed in monocytes/macrophages, (neoangiogenic) endothelial cells and myofibroblasts, which is in line with previously published studies [ 8, 16, 24].
The relatively high age of the female GA patients included in the ACT-CVD cohort is in line with previously published epidemiologic studies [ 24].
Our results, in general, agree in many cases with previously published studies.
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