In line with the involvement of the dorsal hippocampus in spatial memory, the effectiveness of the peptide in the Hebb Williams maze, which contains spatial components, was better when the treatment was performed in this part of the structure.
This result is in line with possible involvement of miR-30a in autophagy-dependent chemoresistance in ovarian cancers.
In-silico ChIP-Seq analysis of the promoters revealed a strong enrichment for PPARG binding (40%% bound, p < 10−6), in line with PPARG involvement in lipid metabolism [ 25].
This is in line with the involvement of the Hap complex in the regulation of mitochondrial functions such as TCA cycle, electron transport chain and respiration.
In line with their involvement in TJ complexes at the BCSFB, immunoreactivity of Cld-9 and -19 was localized at intercellular junctions of the epithelium in both LVCP and 4VCP.
In line with the involvement of the cytoskeleton in cell motility and invasion, the Ena/VASP family of actin-regulatory proteins is implicated in metastasis; for example, Mena is upregulated in several human cancers.
This is in line with an involvement of medial frontal neural generators during exhibition of reward hypersensitivity in gamblers [ 10], economic choices [ 11], error detection [ 12] and deviations of motivational predictions [ 13].
Therefore, CeA seems to play a major role in the promotion of an initial response to stress by corticolimbic catecholamines, in line with its involvement in emotional and behavioural stress responses (Koob 2009) and in the regulation of various neuromodulatory systems (Mirolli et al. 2010), in particular in stressful conditions (Davis and Whalen 2001).
Moreover, evidences of the involvement of ERK1/2 in regulation of PLIN2 expression and the growth of LDs [ 41] give support to our findings of increased protein expression of PLIN2 seen under MT-II stimulus, and is in line with the involvement of ERK1/2 in biogenesis of LDs induced by this PLA2 homologue.
These results are in line with the involvement of IL-6 signalling, with STAT1 and STAT3 as potential targets, which was demonstrated in CRC cell lines by us and others (Heinrich et al, 2003; Corvinus et al, 2005; Zugowski et al, 2011).
