These observations suggest that the combination of a single functional allele lacking some external signal/co-factor might result in failure to reach a certain threshold of expression leading to complete loss of Cdx2 and polyp development, which is in line with a self-regulatory mechanism.
Overall, our observations are in line with a complex interplay of regulatory mechanisms operating in bacteria, and the lack of correlation between mRNA and protein levels observed in E. coli [50], [51].
Although there are no data on IL-10 production in anti-PD1-treated T. gondii-infected mice, these previously reported findings are in line with a PD-1/PD-L1 counter-regulatory pathway.
Collectively, our findings on aging-associated expression of cell cycle regulatory proteins are in line with a role of reduced proliferation capacity of aged fibroblast discussed in skin aging and provide candidate proteins for further functional validation of this concept.
However, T. crassiceps infection did not induce higher numbers of T regulatory cells, which is in line with a previous finding on the effect of this infection on experimental autoimmune encephalomyelitis [ 18].
The regulatory mutations in isolation all increase transport, in line with a common reduction in negative regulation by RpoS.
"In short, in line with the regulatory framework we have made an application for a scientific and independent regulatory assessment for limited and targeted use of a neonicotinoid product in two specific contexts in the UK this season.
The psychometric properties (validity, reliability and ability to detect change) of each PRO for an SLE population were also assessed in line with FDA regulatory guidance for the development and validation of PROs [ 11],[ 23].
In line with known regulatory roles of Cdc42, we found that Frabin/Fgd4 regulates Schwann cell endocytosis, a process that is increasingly recognized as a relevant mechanism in peripheral nerve pathophysiology.
In the first quarter, JPMorgan changed its risk measurement to one it felt was more in line with recent regulatory changes involving capital requirements.
