This exquisite lineage restriction was particularly surprising in light of the expression of multiple pan-mesodermal marker genes, such as LHX1, MESP1 and MIXL1.
In light of the expression data in response to fasting, UCP2B is likely the homolog of the UCP2 described in other vertebrates.
In light of the expression of CD31, reported to be a ligand of CD38, in the endothelium, a role of CD38 in CLL cell extravasation appears logical.
The fact that adult fecundity is affected by loss of mir-35 -41 is intriguing in light of the expression pattern of the mir-35 family: primarily in oocytes and early embryos.
Of note, the neuropeptides α-MSH and NPY have been demonstrated to increase and decrease lipolysis, respectively, in fully differentiated 3T3-L1 adipocytes [ 42], so by analogy, direct effects of VGF peptides on adipocytes are also possible, particularly in light of the expression of VGF in BAT and in the sympathetic nervous system [ 85, 86].
In light of this, severely restricted expression of one of the still functional paralogs could also be a factor in the apparent excess of single gene families of pHaps in relation to the genomic data.
In light of this, the gene expression models derived in our investigation warrant further examination, validation, and possible refinement in a clinical trial setting in order to be adopted as routine clinical tests.
But on Friday, Elan said that it would put itself up for sale "in light of the expressions of interest received to date" and that "Royalty Pharma will be invited to participate if they so wish".
In light of this, enhanced MMP-9 expression by macrophages upon exposure to ZOL-LIP may be beneficial in the tumour microenvironment.
In light of this information, CYP4BL transcript expression was measured in all G. ventalina, P. homomalla and control-fed snails with general-cyp4BL primers, and the data were reanalyzed excluding Shark Rock reef, which contained snails with negligible CYP4BL sub A) transcript expression levels.
In light of this established correlation between PDGFRα expression and bone-metastatic potential, we tested whether the exogenous over-expression of receptor in PC3-N and DU-145 cells could sustain initial bone colonization and promote metastatic growth of these two malignant phenotypes.
