Sentence examples for in light of defects from inspiring English sources

In light of defects in mitochondrial structure described above, we assessed whether there was any alteration in mitochondrial membrane potential (Δψm) in cumulus cells of diabetic mice.

While the pathogenesis of ADPKD is often viewed in light of defects in trans-epithelial fluid transport and associated channels causing massive and abundant cyst formation, it is becoming increasingly clear that ADPKD is also a disease of disordered epithelial cell cycle regulation and apoptosis.

The small sample size in our study limits the interpretation of the observed regenerative effects in light of the defect morphology.

In light of the above issues, defects in resection are associated with defects in both HR and DNA-damage signaling.

Finally, in light of observed DA axon defects in E18 Wnt5a−/− embryos, and our expression gradients identified in Figure 1, we examined an earlier time point (E12) to determine the effect of Wnt5a ablation on the establishment of the DA pathways.

In light of these extensive anatomical defects and the existing body of literature on mouse ataxia, the remarkable preservation of forward paw motion in pcd was surprising.

In light of those studies and the defects observed in the trpm7 j124e1 and trpm7 b508 mutants (Elizondo et al., 2005; McNeill et al., 2007) (this study), we hypothesize that the kinase domain of Trpm7 is required for its functional role in normal development.

The mechanisms underlying these vascular defects have been unclear, but in light of the present work, a contribution of defective Wnt/β-catenin signaling seems possible.

It is well established that integrins and SFKs are essential for cell movement, and in light of the platelet-spreading and αIIbβ3 signaling defects observed in CD148-deficient platelets, we hypothesized that megakaryocytes would exhibit similar functional defects.

In light of such diverse activities, it seems remarkable that several developmental defects associated with elp/mop mutants could be explained essentially by aberrations in auxin-controlled morphogenesis.

In light of this perspective, the finding that ubp2Δ mutants have a defect in Rsp5-mediated transporter and receptor sorting reported here is especially surprising.