Restricting the analysis to patients in the vancomycin group whose isolates' minimum inhibitory concentrations were below 2 µg/mL resulted in a larger risk ratio in favour of vancomycin (1.64, 0.99 to 2.68).
Digital has been seen as the long-term risk in news businesses, with its uncertain revenues and peripatetic audiences, but the larger risk remains in print.
By far the larger risk was in growing too slow.
"Cleantech investing is mostly large in scale, large in risk and large in potential rewards," Dolezalek says.
In fact, large risk based variation in treatment benefit with metformin suggests that outcomes nearly equivalent to treating the entire Diabetes Prevention Program cohort can be achieved by treating only the quarter of the patients at highest risk.
That could force other investors, in turn, to take larger risks in the face of lower returns.
If potential expenses are properly socialized, then gains and losses average out in the large risk pool, and the total savings required is much less.
The available limited prospective data in small samples need to be substantiated by a longitudinal approach in larger at-risk cohorts.
It is suggested that a search for space-time clustering of NPC cases in larger high-risk populations might prove more fruitful.
When stratifying our analyses by smoking status we found larger risks in never-smokers than in smokers.
