Exact(1)
Although the number of subjects included in the clinical trial with RTS,S/AS02A and MVA-CS was small, such exploratory studies with real time RT-PCR may help to guide the selection of immune markers for analysis in larger efficacy trials.
Similar(59)
VaxGen sold the rights to develop the product to Global Solutions for Infectious Diseases after the product failed in large efficacy trials when tested alone.
Rigorous evaluation of formulated products prior to inclusion in large efficacy studies should be done to ensure successful outcomes.
For example, systemic and intracellular azithromycin PK has been evaluated in small studies in CF, but larger efficacy studies in CF have not collected PK information that would enable evaluation of target concentrations.
Thirdly, drug coated balloons might exert a larger efficacy in BMS-ISR than in DES-ISR.
A larger efficacy study in 4000 people is planned for later this year.
Fauci says $56 million of the total would go toward a larger efficacy trial in Liberia, which would include both the NIAID/GSK vaccine and another made by NewLink Genetics of Ames, Iowa (pending more data from ongoing safety trials).
Collum [ 22] was deemed a potential outlier based on larger efficacy effect in favor of ACV.
This pharmacokinetic study was nested into a larger efficacy trial in 500 patients with P. vivax malaria infections.
This is consistent with the 6-mo persistent infection results observed in the initial study, and with previous observations of VE against persistent HPV-16/18 HPV-16/18 infectionr age groups, whinh were reported for both 6-mo and 12-mo persimilar infections in the lagee groups trial PATRICIA and for 12-mo persistent infections in a large efficacy trial in Costa Rica.
Preferential protection of young children with ITNs in a sub-area of NHD was already achieved in a large efficacy study, pointing to the effects of clear instructions to the population [12], [38].
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