Because of the large number of dietary factors explored in this analysis, our findings should be interpreted with caution, warrant further investigation into the etiologic mechanism and warrant confirmation in larger hypothesis-based and pathway-based studies.
Selecting the best subset of features in a large hypothesis space defined by all possible combinations of features is a well-known issue in machine learning.
We consider the observations in this exploratory hypothesis-generating study interesting enough to merit validation in a larger hypothesis driven study, testing the correlation between GR binding capacity and outcome.
We also comment on the potential of causal ordering for emerging applications in large-scale hypothesis management and analytics.
We must study ordinary people--with no hypothesis--in large numbers," he says.
However, the scientific value, utility and feasibility of histopathology in large-scale hypothesis-generating clinical screening of mutant mice have not been systematically evaluated.
We therefore followed the approach proposed by Storey et al., and we estimated the false discovery rate (FDR), more appropriate in large sets of hypotheses than multiple testing procedures [ 37].
Testing these hypotheses in large epidemiological studies is now technically straightforward and significant polymorphisms are likely to be identified in the near future.
However, not all mineral licks have higher nutrient concentrations and thus the ability to buffer the effects of PSM, which may be harmful if consumed in large quantities, is an alternative hypothesis for geophagy in the tropics.
These findings support the hypothesis that, in large countries, social distancing measures (e.g. school and non essential workplaces closure, case isolation), travel restrictions and pharmaceutical measures based on antiviral treatment of index cases and prophylaxis to close contacts will be key in mitigating and delaying the epidemic as long as the pandemic vaccine is not available.
