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Safety data in large case series, some that lasted for many years, have also been published.
Rituximab (a chimeric monoclonal anti-CD 20 antibody) was the first promising biologic agent showing interesting results in large case series but 2 phases III randomised studies didn't reach their primary objective.
Nevertheless, comprehensive descriptions of CM clinical features, risk factors and comorbidity in large case series are very scarce.
Nevertheless, in large case series with similar neck adapters applied, no case of dissociation was reported [21].
19 Genome-wide association studies (GWAS) use panels of up to a million or more SNPs to identify common gene variants in large case and control samples.
Up to date, no therapy has demonstrated in large case studies to be effective in preventing the progression of heart injury and in reversing autoantibody-associated CHB.
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The results are quite significant, but in large cases, the execution time does not meet the expected objectives.
It also encourages a more active judicial supervision of discovery in large cases to evaluate whether the evidence produced at any point warrants further discovery.
Promising new LOAD genes such as SORL1 [8], GAB2 [9], PCDH11X [10], PICALM [11], CLU [11], [12] and CR1 [12], [12] are, however, now being identified through genome-wide association studies and follow-up analyses in large case-control series.
The data provided here will enable subsequent studies that specifically address the distribution of the three main haplotypes and the corresponding genotypes in large case-control settings.
In larger case series, the mortality was 1.6% overall.
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