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Some worried that mention of minor abnormalities in laboratory values — for example, a slightly elevated prostate specific antigen or white blood cell count — could cause patients to worry unduly about some dread disease.
Antepartum changes in laboratory values from diagnosis to delivery were evaluated by means of the Kruskal-Wallis test.
As in the training set, there were differences in laboratory values between patients with S. aureus infection and healthy controls (Table 2).
We estimate risk reduction of initiating medications based on the UKPDS risk equation by incorporating the changes in laboratory values after initiating medication.
Changes in laboratory values were presented descriptively.
There were no clinically relevant mean changes in laboratory values.
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Conversely, some ADRs may only be detected by change in laboratory value, for example drug-induced neutropenia or anemia.
Treatment was accompanied either by no change or only small and meaningless changes in the laboratory values considered in the study.
Thus, in this large study, mean changes in some laboratory values were statistically significant, but small in magnitude and of doubtful clinical relevance.
Nevertheless, in particular laboratory values were lacking in a substantial part of the study subjects.
The results presented here may not be generalisable to situations in which laboratory values are missing in a biased, non-random way.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com