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These findings are in keeping with the previous observations that ECS is a discriminatory and significant predictor for prognosis of patients with HNSCCs (Noguchi et al, 1999; Prim et al, 1999; Shingaki et al, 1999; Myers et al, 2001; Greenberg et al, 2003; Woolgar et al, 2003; Wenzel et al, 2004; Larsen et al, 2009).
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Collectively, the MC1R variants we detected were over-represented in the patients with light skin and red or fair hair, in keeping with these previous observations.
Further assessment showed that AEE788 alone or in combination with endocrine agents also increased the expression of ESR1 in keeping with our previous observations at the protein level.
This is in keeping with our previous observations that the cisoid conformation is preferred when the anion is coordinated to a metal ion, while the transoid is preferred for noncoordinating cations.
The results are in keeping with the experimental observations.
The ability of adenosine to close KCa3.1 is in keeping with our previous observations that this channel is closed by the Gαs-coupled β2-adrenoceptor 18.
The ability of PGE2 to close KCa3.1 is in keeping with our previous observations that this channel is closed by Gs-coupled β2-adrenoceptors 9 and Gs-coupled adenosine A2A receptors 10.
In keeping with our previous observations [ 26], mast cell numbers were significantly increased in the islets of the AMS compared to BMS patients (medians 22.6 versus 0.7 cells/mm, p < 0.001).
Untreated Kasumi-1 cells showed weak H4 and H3 acetylation, in keeping with our previous observations., HDACi treatment markedly induced H4 and H3 acetylation, the effect of SAHA being more rapid.
However, and in keeping with our previous observations in muscle-invasive urothelial carcinomas (Korkolopoulou et al, 2005), median values of MCM-5 were significantly higher than those of Ki-67 in ovarian carcinomas as well as in LMP tumours.
This finding was in keeping with the observations of other independent reports [ 12- 15].
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