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We thus hypothesise that Cuc IIa arrests cell cycle progression and results in cell death in the following working model.
In our working model, the role of NM1 at class II promoters is dictated by its motor activity.
This is indicated with a question mark in our current working model shown in Fig. 4. We also examined the kinetics of endogenous complex formation at different time points following atRA treatment (Fig. 3D).
In this working model, FAS inhibition could induce a shift in the equilibrium between transport of Her-2/neu to and from the membrane favoring an increased Her-2/neu internalization followed by intracellular degradation, thus enhancing the mechanism of action of the anti-Her-2/neu antibody trastuzumab.
In our working model, we propose that a decrease in a survival/proliferative signal results in a reduction in T cell size and a delay in cell proliferation.
The complexity and inter-dependency of tight junction functions and processes can be outlined in a working model (Fig. 14B).
In our working model (Fig. 8), the only two types of immune cells involved are microglia and recruited peripheral macrophage-like cells.
In our working model, behavioral attraction to higher odor concentrations of vinegar is the sum of the opposing effects of Or42b and Or85a.
In our working model, SAD-2 is a protein that interacts with SAD-1 and helps transport it to the perinuclear region, whereas QIP is an exonuclease that removes the passenger strand of an siRNA duplex.
In a working model, Sec17 and SMs accelerate fusion mediated by cognate SNARE complexes and protect them from NSF-mediated disassembly, while mis-assembled or non-cognate SNARE complexes are eliminated through kinetic proofreading by Sec18.
The mechanisms that underlie the enhanced growth-suppressive action of HDAC inhibitors and ML-60218 may at least partially involve reversal of HDAC inhibitors-stimulated, up-regulated expression of tRNA as illustrated in the working model (Fig. 7B).
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