Exact(1)
Although HT61 has lower bactericidal activity against multiplying bacteria than marketed antibiotics, it is used in such a high concentration in its topical formulation (currently 1% v/v, 10 mg/ml) that this should compensate for this weakness.
Similar(59)
However, the reactive propensity of resveratrol also limits its use in topical formulations.
Diacerein in the topical formulation is hydrolyzed to rhein in the epidermis and dermis following administration.
Remarkably, a sustained > 40% luc2p inhibition was observed after two 1-hour treatments with Accell-siRNAs in our topical formulation.
A full understanding of the mode of action could be beneficial for the design of potent enhancers and for the choice of the enhancer to be used in the topical formulation of a special drug.
Imiquimod, an immune-modulating imidazoquinoline compound, has been approved in topical formulation for the treatment of actinic keratoses, superficial basal cell carcinomas, and external genital warts.
3 Lactic acid, with optimal biologic activity in its l-form, is also used in various topical formulations to exfoliate the skin and also to provide antiaging properties.
Considering the evidence of biological activity of mNGF in the eye, a topical formulation of rhNGF produced in Escherichia coli has been developed for the treatment of ocular diseases.
Benzocaine (BZC) is a local anesthetic that presents limited application in topical formulations due to its low water-solubility.
However, besides their similar indication, they have different mechanisms of action and thus they may have different effects on the skin; in addition, since the topical formulation efficiency depends on vehicle characteristics, the ingredients of the formulation could alter their effects.
For this reason, there have been no reported investigations of the skin-whitening effect of GSH in topical formulations, unlike in oral formulations.
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