Sentence examples for in its substrates from inspiring English sources
From an outstanding paper I would expect either a systematic and unbiased approach to identifying the substrates of the putative chaperone complex or a delineation of the features that it recognizes in its substrates or some direct evidence for the actual chaperone activity proposed.
We have provided evidence that CAPN3 recognizes a primary sequence motif in its substrates.
The caspase family consists of cysteine proteases that cleave the peptide bond next to an asparatic acid in its substrates.
Scopelophila cataractae, one of the so-called copper mosses, not only tolerates extremely high concentrations of metals in its substrates, but requires these substrates for optimum growth.
However, the anaphase promoting complex (APC/C) preferentially ubiquitinates an initiation motif in its substrates (Williamson et al., 2011), suggesting that ubiquitination may, in some cases, be sequence specific.
Rsp5 contains three WW domains that promote binding to [L/P]PxY motifs in its substrates (Kasanov et al. 2001); however, many Rsp5-dependent substrates, including transmembrane proteins, lack [L/P]PxY motifs.
The designed enzyme is thus similar to natural d-threonine aldolases in its substrate specificity and stereoselectivity.
Among all PRT enzymes of purine salvage pathway in Leishmania, XPRT (Xanthine phosphoribosyl transferase) is unique in its substrate specificity and their non-existence in human.
Perhaps, the Ct domain is involved in its substrate specificity to proteases, the affinity to proteases, the conformation change of proteases, the protection from degradation caused by non-cysteine proteases, or allosteric regulation of inhibitory activity against proteases.
Preventing binding of 4-hydroxyphenylpyruvate to the hydroxymandelate synthase by introducing a S201V replacement in its substrate binding site nearly completely prevented HMA production but increased MA production only 3.5-fold.
Pin1 (Protein interacting with NIMA1) is a peptidyl prolyl cis trans isomerase (PPIase) which specifically catalyze the conformational conversion of the amide bond of pSer/Thr-Pro motifs in its substrate proteins and is a novel promising anticancer target.
