It was a case of safe-space thinking in its most aggressive form: "we," united in our shared experience, are uncomfortable with things that she, an outsider, has done, and so she must be punished and prevented from repeating her offense.
Likewise, when social media is used toward the end of the book as an example of how we might come to think of humanity as a universal extended family, I couldn't help but want for at least a discussion of how its use can also result in extreme alienation, such as in the most aggressive forms of online trolling and cyber-bullying.
C-Kit and PDGF-R were detected in neuroblastoma [ 132– 134], and the cytokine receptor seems to be expressed mainly in the most aggressive forms of the tumour [ 135].
Our results show that AT1-R and AT2-R proteins are overexpressed in the most aggressive forms of RCCC and that AT2-R expression correlates with PFS.
As aberrations in the TP53 gene and t(4:14) translocations are seen in ∼15% of patients and correlated with short progression-free survival and resistance to alkylating agents at relapse, the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM.
The common observation was that this couple of microRNAs, or at least one of them, is significantly upregulated in tumors versus normal tissues, and often its expression marks the most aggressive forms of human solid tumors.
A particular hallmark of NB is its heterogeneity, in which some tumours regress spontaneously or with limited treatment while the most aggressive forms, especially in elder children (>1 year of age), have metastasised already at the time of diagnosis and are often resistant even to aggressive multimodal therapy [ 12].
In this context melanoma is the most aggressive forms of skin cancer, with high metastatic potential and extraordinary resistance to cytotoxic agents [ 9] and it is resistant to all current modalities of cancer therapy.
There is abundant evidence that hyperactivation of the canonical Wnt signaling pathway promotes tumorigenesis in experimental systems, while observational data demonstrate that the pathway is frequently activated in human breast tumors, especially in basal-like carcinomas, one of the most aggressive forms of the disease [ 1- 3].
Among all the ROS produced, OH radicals are among the most aggressive forms implied in cellular oxidative stress [1] [2].
